Hedgehog signalling in cancerLOEWE Junior Research Group | |
| Adresse | zurzeit:
Karolinska Institute, Dept. Biosciences Huddinge Sweden Telefon: 0046-8-608-3303 |
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| Internet | http://www.imt.uni-marburg.de/loewe/Gruppe.php |
| Leiter | Dr. Matthias Lauth |
| Förderung | seit: 2009 |
| Förderinstitution | Land Hessen: LOEWE |
| Programm | In the mammalian embryo, approximately a handful of signal transduction pathways are involved in orchestrating the key steps of embryogenesis. One of theses instructive cues is represented by the Hedgehog (Hh) signalling pathway, which induces such diverse cellular responses as proliferation, differentiation or neuronal guidance, depending on the biological context [Hooper et al. (2005), Nat Rev Mol Cell Biol 6, 306-317]. Pattern formation in tissues such as the skin, brain and the neural tube, or the developing limbs has been shown to be subject to regulation by Hh signalling. Improper Hh signalling is a major cause of holoprosencephaly, the most common child birth defect. In postnatal life, the Hh pathway is spatially restricted and its proposed role is in the induction of proliferation of adult stem cells, which are required for tissue maintenance and repair [Beachy et al. (2004), Nature 432, 324-331]. Persistent or aberrantly reactivated signalling is associated with hyperproliferative disease and tumour development. It is currently estimated that approximately one third of all cancer deaths are linked to erroneous Hh pathway activation [Lum et al. (2004), Science 304, 1755-1759].
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| Projekte | Evaluation der DYRK1A Kinase als anti-Tumor Zielstruktur in der Behandlung des Pankreaskarzinoms | Identifikation neuer Proteinsubstrate der tumorigenen Kinase Dyrk1B | Charakterisierung der DyrK1B Kinase als ein Ghi-spezifischer Inhibitor des hedgehog Signalweges |
